Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 5/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.47 |
| ▸ | HTR6 | P50406 | 7/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533861 | 0.92 | ADRA2A (0.47) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9534202 | 0.84 | ADRA2A (0.51) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9538620 | 0.84 | ADRA2A (0.44) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9535348 | 0.82 | ADRA2A (0.51) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9537541 | 0.81 | ADRA2A (0.47) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9533895 | 0.80 | ADRA2A (0.47) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9533899 | 0.80 | ADRA2A (0.47) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9533714 | 0.80 | ADRA1A (0.57) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9533699 | 0.77 | ADRA2A (0.47) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9534823 | 0.77 | ADRA2A (0.51) | ADRA2AADRA1AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384676-B1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1993-11-10 | — | — | EP | disclosed |
| US-4981849-A | OBESITY, DIABETES, CARDIOVASCULAR DISORDERS, DEPRESSION | SMITHKLINE BEECHAM CORPORATION (US) | 1991-01-01 | — | — | US | disclosed |
| EP-0384676-A1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |