Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 8/20 | 0.43 |
| ▸ | NPC1 | O15118 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9184518 | 0.78 | MAPT (0.44) | KDM4EMAPTDDAH1ADRA2CELANE | |
| SCHEMBL9531515 | 0.78 | DDAH1 (0.71) | MAPTDDAH1ADRA2CHSD17B10RAB9A | |
| SCHEMBL1748063 | 0.77 | KDM4E (0.56) | KDM4EMAPTELANEHSD17B10RAB9A | |
| SCHEMBL4714803 | 0.77 | RAB9A (0.54) | KDM4EMAPTELANERAB9ANPC1 | |
| SCHEMBL9534071 | 0.73 | TMEM97 (0.62) | KDM4EMAPTDDAH1ADRA2CHSD17B10 | |
| SCHEMBL15447660 | 0.72 | KDM4E (0.74) | KDM4EMAPTELANEHSD17B10RAB9A | |
| SCHEMBL31294143 | 0.72 | KDM4E (0.50) | KDM4EMAPTELANEHSD17B10RAB9A | |
| SCHEMBL5541680 | 0.69 | KDM4E (0.63) | KDM4EMAPTELANEHSD17B10RAB9A | |
| SCHEMBL9534339 | 0.69 | DDAH1 (0.67) | MAPTDDAH1ADRA2CHSD17B10RAB9A | |
| SCHEMBL28874557 | 0.69 | MAPT (0.55) | KDM4EMAPTELANEHSD17B10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0335586-B1 | PIPERIDINE & PIPERAZINE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | UBE INDUSTRIES, LTD. (JP) | 1993-06-02 | — | — | EP | disclosed |
| US-4929618-A | ANTIALLERGENS, ANTIHISTAMINES | UBE INDUSTRIES, LTD. (JP) | 1990-05-29 | — | — | US | disclosed |
| EP-0335586-A1 | Piperidine & piperazine derivatives, process for preparing the same and pharmaceutical compositions containing the same | UBE INDUSTRIES, LTD. (JP) | 1989-10-04 | — | — | EP | disclosed |