Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 5/20 | 0.48 |
| ▸ | NOS1 | P29475 | 4/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536585 | 0.93 | NOS2 (0.48) | NOS2NOS1NOS3KDM4EALDH1A1 | |
| Oxalic Acid SCHEMBL9537287 | 0.90 | NOS2 (0.46) | NOS2NOS1NOS3KDM4EALDH1A1 | |
| Oxalic Acid SCHEMBL9537280 | 0.90 | NOS2 (0.46) | NOS2NOS1NOS3KDM4EALDH1A1 | |
| SCHEMBL7985310 | 0.88 | KDM4E (0.56) | NOS2KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL9536951 | 0.84 | KDM4E (0.53) | NOS2KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL10428791 | 0.83 | LMNA (0.57) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL9687534 | 0.82 | NOS2 (0.45) | NOS2NOS1NOS3KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10428895 | 0.81 | LMNA (0.55) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL9536529 | 0.81 | NOS2 (0.55) | NOS2NOS1NOS3KDM4EALDH1A1 | |
| Oxalic Acid SCHEMBL10383259 | 0.81 | CYP3A4 (0.38) | NOS2NOS1NOS3ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282133-B1 | 1-ALKYL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-28 | — | — | EP | disclosed |
| US-4943580-A | ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |
| EP-0282133-A2 | 1-alkyl substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-09-14 | — | — | EP | disclosed |