Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31084647 | 0.87 | MAPT (0.45) | MAPTHRH1SIGMAR1ALDH1A1TSHR | |
| SCHEMBL23647320 | 0.84 | CASR (0.46) | MAPTALDH1A1TSHR | |
| SCHEMBL6312404 | 0.79 | ACHE (0.47) | MAPTHRH1ALDH1A1 | |
| SCHEMBL11319195 | 0.79 | SMN1; SMN2 (0.54) | MAPTHRH1ALDH1A1TSHR | |
| SCHEMBL11306755 | 0.77 | SMN1; SMN2 (0.55) | MAPTHRH1ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL7534025 | 0.74 | SMN1; SMN2 (0.49) | HRH3HRH1ALDH1A1 | |
| SCHEMBL9672230 | 0.73 | HRH3 (0.54) | HRH3SIGMAR1ALDH1A1 | |
| SCHEMBL9536249 | 0.72 | KDM4E (0.53) | ALDH1A1 | |
| SCHEMBL12894447 | 0.72 | PLAU (0.46) | — | |
| SCHEMBL29180050 | 0.70 | ALDH1A1 (0.43) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| EP-0533781-A1 | 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVES AND ANALOGS AS HYPOGLYCEMIC AGENTS. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |