Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 6/20 | 0.33 |
| ▸ | MAOB | P27338 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533856 | 0.85 | ADRA2A (0.65) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| Hydrochloric Acid SCHEMBL9536145 | 0.84 | ADRA2A (0.64) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9534435 | 0.75 | ADRA2A (0.62) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9774583 | 0.74 | ADRA2A (0.45) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9378965 | 0.72 | ADRA2A (0.67) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9378713 | 0.72 | ADRA2A (0.67) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9774568 | 0.72 | ADRA2A (0.38) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9774571 | 0.72 | ADRA2A (0.41) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9538544 | 0.72 | KDM4E (0.43) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9533999 | 0.72 | ALDH1A1 (0.45) | ADRA2AADRA1AHTR6ALDH1A1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384676-B1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1993-11-10 | — | — | EP | disclosed |
| US-4981849-A | OBESITY, DIABETES, CARDIOVASCULAR DISORDERS, DEPRESSION | SMITHKLINE BEECHAM CORPORATION (US) | 1991-01-01 | — | — | US | disclosed |
| EP-0384676-A1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |