Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534104 | 0.75 | MAOB (0.58) | MAOBMAPTKDM4EMAPK1KMT2A | |
| SCHEMBL9537036 | 0.75 | MAOB (0.58) | MAOBMAPTKDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL9533087 | 0.74 | MAOB (0.57) | MAOBMAPTKDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL9534595 | 0.72 | MAOB (0.59) | MAOBMAPTPDCD1CD274KMT2A | |
| SCHEMBL1133533 | 0.70 | MAPT (0.55) | MAPTKDM4ESMN1; SMN2PDCD1CD274 | |
| SCHEMBL3535015 | 0.68 | LOX (0.60) | MAPTKDM4EMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL11887425 | 0.68 | MAPT (0.68) | MAPTKDM4EMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL10381797 | 0.67 | MAOB (0.49) | MAOBMAPTKDM4EKMT2AMEN1 | |
| SCHEMBL3534371 | 0.66 | ALDH1A1 (0.39) | MAPTKDM4EMAPK1KMT2AMEN1 | |
| SCHEMBL3529246 | 0.65 | ALDH1A1 (0.40) | MAPTKDM4EMAPK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539372-A1 | THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1993-05-05 | — | — | EP | disclosed |
| WO-1991011448-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1991-08-08 | — | — | WO | disclosed |