Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.59 |
| ▸ | HTR1A | P08908 | 3/20 | 0.59 |
| ▸ | HTR2C | P28335 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 5/20 | 0.45 |
| ▸ | TACR2 | P21452 | 2/20 | 0.45 |
| ▸ | TACR1 | P25103 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10803117 | 0.91 | HTR2C (0.56) | CYP2D6HTR1AHTR2CMEN1CYP3A4 | |
| Bromide SCHEMBL10550913 | 0.90 | HTR2C (0.56) | CYP2D6HTR1AHTR2CMEN1CYP3A4 | |
| SCHEMBL9537351 | 0.90 | HTR1A (0.56) | CYP2D6HTR1AHTR2CMEN1CYP3A4 | |
| Oxalic Acid SCHEMBL10803137 | 0.89 | HTR2C (0.55) | CYP2D6HTR1AHTR2CMEN1CYP3A4 | |
| Oxalic Acid SCHEMBL10803132 | 0.89 | HTR2C (0.55) | CYP2D6HTR1AHTR2CMEN1CYP3A4 | |
| Hydrochloric Acid SCHEMBL9740582 | 0.88 | CYP2D6 (0.56) | CYP2D6HTR1AHTR2CMEN1CYP3A4 | |
| Oxalic Acid SCHEMBL10552172 | 0.86 | HTR2C (0.54) | CYP2D6HTR1AHTR2CMEN1CYP3A4 | |
| Oxalic Acid SCHEMBL10552180 | 0.86 | HTR2C (0.54) | CYP2D6HTR1AHTR2CMEN1CYP3A4 | |
| SCHEMBL9383006 | 0.86 | SSTR5 (0.47) | CYP2D6HTR1AHTR2CMEN1CYP3A4 | |
| SCHEMBL9536489 | 0.85 | ADRA1A (0.48) | CYP2D6HTR1AHTR2CMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |