Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 6/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | TACR2 | P21452 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9536770 | 1.00 | MCHR1 (0.45) | MCHR1SSTR5KCNH2NR4A2HRH1 | |
| SCHEMBL9536509 | 0.88 | RAB9A (0.46) | MCHR1SSTR5KCNH2NR4A2HRH1 | |
| Oxalic Acid SCHEMBL10552513 | 0.85 | SSTR5 (0.51) | MCHR1SSTR5KCNH2NR4A2HRH1 | |
| SCHEMBL9536734 | 0.84 | SSTR5 (0.47) | SSTR5KCNH2NR4A2HRH1CYP2D6 | |
| SCHEMBL10548132 | 0.83 | SSTR5 (0.47) | SSTR5KCNH2NR4A2HRH1CYP2D6 | |
| SCHEMBL9537110 | 0.83 | SSTR5 (0.49) | SSTR5KCNH2NR4A2HRH1CYP2D6 | |
| SCHEMBL10551413 | 0.83 | SSTR5 (0.47) | SSTR5KCNH2NR4A2HRH1CYP2D6 | |
| Oxalic Acid SCHEMBL9538589 | 0.81 | SLC6A9 (0.43) | MCHR1SSTR5KCNH2NR4A2HRH1 | |
| Oxalic Acid SCHEMBL9538585 | 0.81 | SLC6A9 (0.43) | MCHR1SSTR5KCNH2NR4A2HRH1 | |
| SCHEMBL9536807 | 0.81 | SSTR5 (0.50) | SSTR5KCNH2NR4A2HRH1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |