Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1969968 | 0.81 | GRM5 (0.57) | GRM5NPC1RAB9AHPGDCYP1A2 | |
| SCHEMBL7239293 | 0.80 | GRM5 (0.59) | GRM5NPC1RAB9AHPGDCYP1A2 | |
| SCHEMBL3244479 | 0.80 | ALDH1A1 (0.57) | GRM5NPC1RAB9AHPGDCYP1A2 | |
| SCHEMBL2159094 | 0.78 | GRM5 (0.57) | GRM5NPC1RAB9AHPGDCYP1A2 | |
| SCHEMBL5429612 | 0.78 | NPC1 (0.65) | GRM5NPC1RAB9AHPGDCYP1A2 | |
| SCHEMBL5429264 | 0.78 | NPC1 (0.65) | GRM5NPC1RAB9AHPGDCYP1A2 | |
| SCHEMBL12020387 | 0.78 | NPC1 (0.53) | GRM5NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL506708 | 0.78 | NPC1 (0.64) | NPC1RAB9AHPGDCYP1A2CYP2C19 | |
| SCHEMBL9519659 | 0.77 | EPHX1 (0.58) | GRM5NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5424850 | 0.77 | NPC1 (0.62) | GRM5NPC1RAB9AHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417745-B1 | Heteroaryl substituted imidazo [4,5-c] pyridines | SEARLE & CO (US) | 1993-11-03 | — | — | EP | disclosed |
| EP-0417745-A2 | Heteroaryl substituted imidazo [4,5-c] pyridines | G.D. Searle & Co. (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4990518-A | Platelet activating factor | G. D. SEARLE & CO. (US) | 1991-02-05 | — | — | US | disclosed |