Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24983989 | 0.87 | KDM4E (0.50) | MAPTKDM4EALDH1A1DDB1CRBN | |
| SCHEMBL30163962 | 0.87 | KDM4E (0.50) | MAPTKDM4EALDH1A1DDB1CRBN | |
| SCHEMBL9537925 | 0.83 | HTR2B (0.58) | ALDH1A1KMT2AMEN1DDB1CRBN | |
| SCHEMBL9307067 | 0.81 | ALDH1A1 (0.44) | MAPTSMN1; SMN2KDM4ETSHRHSD17B10 | |
| SCHEMBL9537827 | 0.80 | TSHR (0.46) | MAPTSMN1; SMN2KDM4ETSHRHSD17B10 | |
| SCHEMBL14685201 | 0.80 | DDB1 (0.58) | MAPTSMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL7429437 | 0.80 | KMT2A (0.65) | MAPTSMN1; SMN2KDM4ETSHRHSD17B10 | |
| SCHEMBL6995118 | 0.80 | KDM4E (0.63) | MAPTSMN1; SMN2KDM4ETSHRHSD17B10 | |
| SCHEMBL9536891 | 0.79 | ALDH1A1 (0.47) | MAPTSMN1; SMN2KDM4ETSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL9537839 | 0.79 | HSD17B10 (0.52) | MAPTSMN1; SMN2KDM4ETSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |