Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.68 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.62 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.62 |
| ▸ | DHODH | Q02127 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | GFER | P55789 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | FABP4 | P15090 | 2/20 | 0.61 |
| ▸ | FABP3 | P05413 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | NGLY1 | Q96IV0 | 1/20 | 0.60 |
| ▸ | CTSV | O60911 | 1/20 | 0.59 |
| ▸ | CTSL | P07711 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31500229 | 0.91 | AKR1C3 (0.72) | MPOAKR1C3AKR1C2DHODHMEN1 | |
| SCHEMBL11604753 | 0.87 | KDM4E (0.68) | MPOAKR1C3AKR1C2DHODHMEN1 | |
| SCHEMBL846925 | 0.87 | AKR1C3 (0.59) | MPOAKR1C3AKR1C2DHODHMEN1 | |
| SCHEMBL5927337 | 0.87 | MPO (0.53) | MPOAKR1C3AKR1C2DHODHMEN1 | |
| SCHEMBL11020710 | 0.87 | AKR1C3 (0.62) | MPOAKR1C3AKR1C2DHODHMEN1 | |
| SCHEMBL9515604 | 0.86 | GRIK1 (0.69) | AKR1C3AKR1C2MEN1GFERKMT2A | |
| SCHEMBL11603203 | 0.86 | FABP4 (0.69) | MPOAKR1C3AKR1C2DHODHMEN1 | |
| SCHEMBL14598921 | 0.86 | MAPT (0.65) | MPOAKR1C3AKR1C2DHODHMEN1 | |
| SCHEMBL10836320 | 0.85 | GRIK1 (0.59) | MPOAKR1C3AKR1C2DHODHMEN1 | |
| SCHEMBL28741324 | 0.85 | MPO (0.70) | MPOAKR1C3AKR1C2DHODHMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| CN-85109061-A | The preparation method of novel acid benzazolyl compounds | — | 1987-01-21 | — | — | CN | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |