Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 2/20 | 0.52 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538842 | 0.92 | SSTR5 (0.52) | SSTR5CCR3HRH3ALDH1A1RAB9A | |
| SCHEMBL9536543 | 0.89 | SSTR5 (0.66) | SSTR5ALDH1A1RAB9AMEN1CYP1A2 | |
| SCHEMBL9537500 | 0.84 | KCNH2 (0.46) | HRH3RAB9ACYP2D6 | |
| SCHEMBL9564956 | 0.83 | CYP1A2 (0.54) | SSTR5CCR3ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9537151 | 0.83 | SSTR5 (0.59) | SSTR5ALDH1A1RAB9AMEN1CYP1A2 | |
| SCHEMBL9536730 | 0.83 | SSTR5 (0.52) | SSTR5RAB9AMEN1KMT2A | |
| SCHEMBL9537851 | 0.82 | MEN1 (0.56) | SSTR5CCR3HRH3ALDH1A1MEN1 | |
| SCHEMBL10547773 | 0.82 | HTR1A (0.56) | SSTR5HRH3MEN1CYP1A2CYP2D6 | |
| SCHEMBL9536547 | 0.82 | SSTR5 (0.52) | SSTR5CCR3ALDH1A1SLC6A4SLC6A3 | |
| SCHEMBL5626341 | 0.81 | MEN1 (0.66) | SSTR5CCR3ALDH1A1MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |