Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | TACR2 | P21452 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10547215 | 0.89 | POLB (0.49) | POLBHRH1CYP2D6CHRM1KCNH2 | |
| SCHEMBL9538781 | 0.87 | HRH1 (0.48) | POLBHRH1CYP2D6CHRM1KCNH2 | |
| SCHEMBL9536186 | 0.87 | MAPT (0.56) | POLBSSTR5SLC6A2SLC6A4TP53 | |
| Water SCHEMBL9739944 | 0.85 | SSTR5 (0.62) | HRH1CYP2D6CHRM1KCNH2TACR2 | |
| SCHEMBL9535357 | 0.85 | KMT2A (0.48) | POLBSLC6A2SLC6A4 | |
| SCHEMBL9536847 | 0.85 | KCNH2 (0.49) | POLBHRH1CYP2D6CHRM1KCNH2 | |
| SCHEMBL9538348 | 0.85 | POLB (0.49) | POLBHRH1CYP2D6CHRM1KCNH2 | |
| SCHEMBL10550102 | 0.85 | GNRHR (0.51) | POLBHRH1CYP2D6CHRM1KCNH2 | |
| Oxalic Acid SCHEMBL10552513 | 0.84 | SSTR5 (0.51) | HRH1CYP2D6CHRM1KCNH2TACR2 | |
| SCHEMBL9536266 | 0.84 | OPRK1 (0.51) | POLBHRH1CYP2D6KCNH2TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |