Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11422493 | 0.85 | ATM (0.56) | L3MBTL1ATMTDP1PTGESNPSR1 | |
| SCHEMBL10957777 | 0.85 | L3MBTL1 (0.56) | L3MBTL1ATMTDP1PTGESNPSR1 | |
| SCHEMBL28333250 | 0.82 | ATM (0.53) | L3MBTL1ATMTDP1HDAC1HDAC6 | |
| SCHEMBL3483438 | 0.81 | L3MBTL1 (0.59) | L3MBTL1ATMTDP1PTGESNPSR1 | |
| SCHEMBL4089380 | 0.81 | ALDH1A1 (0.61) | L3MBTL1ATMTDP1PTGESNPSR1 | |
| SCHEMBL9359346 | 0.81 | L3MBTL1 (0.59) | L3MBTL1ATMTDP1PTGESNPSR1 | |
| SCHEMBL4046453 | 0.81 | HDAC3 (0.49) | L3MBTL1HDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL6240933 | 0.78 | SMN1; SMN2 (0.56) | L3MBTL1HDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL7791465 | 0.77 | HDAC3 (0.51) | HDAC3HDAC4HDAC1HDAC2HDAC10 | |
| SCHEMBL9534399 | 0.77 | ATM (0.50) | L3MBTL1ATMTDP1NPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555251-A1 | THIAZOLIDINE DIONE DERIVATIVES | BEECHAM GROUP plc (GB) | 1993-08-18 | — | — | EP | disclosed |
| WO-1992007838-A1 | THIAZOLIDINE DIONE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1992-05-14 | — | — | WO | disclosed |