Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9629039 | 0.90 | EGLN1 (0.34) | PGRMEN1KMT2AALDH1A1GAA | |
| SCHEMBL9629185 | 0.89 | PGR (0.36) | PGRMEN1KMT2AALDH1A1ADCY2 | |
| SCHEMBL9629835 | 0.86 | EGLN1 (0.34) | PGRMEN1KMT2AALDH1A1GAA | |
| SCHEMBL9628874 | 0.83 | EGLN1 (0.36) | PGRMEN1KMT2AALDH1A1GAA | |
| SCHEMBL9348228 | 0.82 | PGR (0.55) | PGRMEN1KMT2AELANECYP11B2 | |
| SCHEMBL9628950 | 0.81 | MAPT (0.38) | MEN1KMT2AALDH1A1GAAADCY2 | |
| SCHEMBL9352368 | 0.70 | PGR (0.42) | PGRMEN1KMT2AALDH1A1GAA | |
| SCHEMBL9348254 | 0.70 | PGR (0.43) | PGRMEN1KMT2AALDH1A1 | |
| SCHEMBL9348253 | 0.70 | POLB (0.44) | PGRMEN1KMT2AELANEALDH1A1 | |
| SCHEMBL9348086 | 0.70 | PGR (0.44) | PGRALDH1A1GAAMAPTKAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0241291-B1 | ARYL-SUBSTITUTED NAPHTHYRIDINE AND PYRIDOPYRAZINE DERIVATIVES | SCHERING CORPORATION (US) | 1993-06-02 | — | — | EP | disclosed |
| US-5011860-A | Aryl-substituted naphthyridine and pyridopyrazine derivatives and their use in treating hyperproliferative skin diseases | SCHERING CORPORATION (US) | 1991-04-30 | — | — | US | disclosed |
| US-4882332-A | Immune suppression method employing arly-substituted naphthyridine and pyridopyrazine derivatives | SCHERING CORPORATION (US) | 1989-11-21 | — | — | US | disclosed |
| US-4866061-A | TREATMENT OF ALLERGIC REACTIONS, ULCERS, INFLAMMATION | SCHERING CORPORATION (US) | 1989-09-12 | — | — | US | disclosed |
| US-4760073-A | Aryl-substituted naphthyridine and pyridopyrazine derivatives, useful as anti-allergic agents | SCHERING CORPORATION (US) | 1988-07-26 | — | — | US | disclosed |
| EP-0241291-A2 | Aryl-substituted naphthyridine and pyridopyrazine derivatives | SCHERING CORPORATION (US) | 1987-10-14 | — | — | EP | disclosed |