Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537511 | 0.89 | PGR (0.41) | PGRALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL9629039 | 0.88 | EGLN1 (0.34) | PGRKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL9628950 | 0.87 | MAPT (0.38) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL9629835 | 0.85 | EGLN1 (0.34) | PGRKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL9352368 | 0.82 | PGR (0.42) | PGRKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL9628874 | 0.81 | EGLN1 (0.36) | PGRKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL9533735 | 0.75 | LMNA (0.36) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9536299 | 0.71 | MAPT (0.39) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9348228 | 0.71 | PGR (0.55) | PGRMEN1KMT2AMAPTHPGD | |
| SCHEMBL9348203 | 0.70 | NPC1 (0.40) | PGRKDM4EALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0338010-B1 | PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF HYPERPROLIFERATE SKIN DISEASE | SCHERING CORPORATION (US) | 1992-02-05 | — | — | EP | claimed |
| EP-0228416-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING AZANAPHTHALENES | SCHERING CORPORATION (US) | 1990-03-21 | — | — | EP | claimed |
| EP-0144996-B1 | SUBSTITUTED SPIRO PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS AND COMPOSITIONS | SCHERING CORPORATION (US) | 1990-02-28 | — | — | EP | claimed |
| EP-0338010-A1 | PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF HYPERPROLIFERATE SKIN DISEASE. | SCHERING CORP (US) | 1989-10-25 | — | — | EP | claimed |
| WO-1988004172-A1 | PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF HYPERPROLIFERATE SKIN DISEASE | SCHERING CORPORATION (US) | 1988-06-16 | — | — | WO | claimed |
| EP-0228416-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING AZANAPHTHALENES. | SCHERING CORP (US) | 1987-07-15 | — | — | EP | claimed |
| WO-1986007537-A2 | PHARMACEUTICAL COMPOSITIONS CONTAINING AZANAPHTHALENES | SCHERING CORPORATION (US) | 1986-12-31 | — | — | WO | claimed |
| EP-0144996-A2 | Substituted spiro pyridine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions | SCHERING CORPORATION (US) | 1985-06-19 | — | — | EP | claimed |
| EP-0144996-B1 | SUBSTITUTED SPIRO PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS AND COMPOSITIONS | SCHERING CORPORATION (US) | 1990-02-28 | — | — | EP | disclosed |
| US-4775524-A | PSORIASIS | SCHERING CORPORATION (US) | 1988-10-04 | — | — | US | disclosed |
| US-4632923-A | Substituted hetero spiro pyridine derivatives as anti-allergy and anti-inflammatory agents | SCHERING CORPORATION (US) | 1986-12-30 | — | — | US | disclosed |