Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5426553 | 0.85 | HPGD (0.62) | LMNAMEN1KMT2AHSD11B1HDAC1 | |
| SCHEMBL9369331 | 0.81 | LMNA (0.55) | LMNAKDM4EMEN1ALOX15ALOX12 | |
| SCHEMBL9538139 | 0.79 | LMNA (0.49) | LMNAKDM4EMEN1ALOX15ALOX12 | |
| SCHEMBL9537139 | 0.78 | LMNA (0.48) | LMNAKDM4EMEN1ALOX15ALOX12 | |
| SCHEMBL8361113 | 0.77 | LMNA (0.77) | LMNAKDM4EMEN1ALOX15ALOX12 | |
| SCHEMBL9001814 | 0.77 | LMNA (0.66) | LMNAKDM4EMEN1ALOX15ALOX12 | |
| SCHEMBL9538546 | 0.76 | LMNA (0.46) | LMNAKDM4EMEN1ALOX15ALOX12 | |
| SCHEMBL9535466 | 0.75 | LMNA (0.45) | LMNAKDM4EMEN1ALOX15ALOX12 | |
| SCHEMBL9885429 | 0.74 | HDAC1 (0.56) | KDM4EALOX15KMT2AHDAC1HDAC6 | |
| SCHEMBL5429605 | 0.73 | GRM5 (0.54) | LMNAKDM4EMEN1RECQLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417745-B1 | Heteroaryl substituted imidazo [4,5-c] pyridines | SEARLE & CO (US) | 1993-11-03 | — | — | EP | disclosed |
| EP-0417745-A2 | Heteroaryl substituted imidazo [4,5-c] pyridines | G.D. Searle & Co. (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4990518-A | Platelet activating factor | G. D. SEARLE & CO. (US) | 1991-02-05 | — | — | US | disclosed |