Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537794 | 1.00 | HSD17B3 (0.33) | HSD17B3NOTUMADORA3KDM4EHTT | |
| SCHEMBL9538906 | 0.82 | ALDH1A1 (0.35) | KDM4EHTTSMN1; SMN2 | |
| SCHEMBL9538910 | 0.82 | ALDH1A1 (0.35) | KDM4EHTTSMN1; SMN2 | |
| SCHEMBL9539213 | 0.79 | ADORA3 (0.41) | HSD17B3NOTUMADORA3KDM4EHTT | |
| SCHEMBL9539218 | 0.79 | ADORA3 (0.41) | HSD17B3NOTUMADORA3KDM4EHTT | |
| SCHEMBL9538368 | 0.79 | KDM4E (0.33) | HSD17B3ADORA3KDM4EHTTSMN1; SMN2 | |
| SCHEMBL9538370 | 0.79 | KDM4E (0.33) | HSD17B3ADORA3KDM4EHTTSMN1; SMN2 | |
| SCHEMBL9537973 | 0.76 | CES1 (0.48) | NOTUMKDM4EHTTSMN1; SMN2 | |
| SCHEMBL9537965 | 0.76 | CES1 (0.48) | NOTUMKDM4EHTTSMN1; SMN2 | |
| SCHEMBL9537141 | 0.75 | PDE5A (0.42) | ADORA3KDM4EHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0180352-B1 | BENZENE-FUSED HETEROCYCLIC COMPOUND | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-26 | — | — | EP | disclosed |
| US-4767780-A | SUBSTITUTED 1,4-DIHYDRO-(1)-BENZOPYRANO(4,3-C)PYRAZOLES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-08-30 | — | — | US | disclosed |
| US-4675324-A | Substituted pyrazolo [4,3-c]pyridines and their use as uricosuric, diuretic and anti-hypertensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-23 | — | — | US | disclosed |
| EP-0180352-A2 | Benzene-fused heterocyclic compound | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-07 | — | — | EP | disclosed |