Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY6 | O43306 | 1/20 | 0.59 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.59 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.59 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.59 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.59 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.59 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.59 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.59 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.59 |
| ▸ | PNMT | P11086 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 9/20 | 0.41 |
| ▸ | HTR2B | P41595 | 9/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10350481 | 0.98 | ADCY6 (0.57) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| SCHEMBL10567699 | 0.97 | ADCY6 (0.55) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| SCHEMBL10563699 | 0.84 | ADCY6 (0.61) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| SCHEMBL10960423 | 0.83 | MEN1 (0.45) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| SCHEMBL10961119 | 0.83 | ALDH1A1 (0.41) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| Bromide SCHEMBL10350530 | 0.82 | ADCY6 (0.59) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| SCHEMBL10350845 | 0.81 | HTR2C (0.56) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| SCHEMBL10350846 | 0.81 | ADCY6 (0.53) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| Bromide SCHEMBL10350991 | 0.80 | HTR2C (0.55) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| Bromide SCHEMBL10350525 | 0.80 | ADCY6 (0.52) | ADCY6ADCY3ADCY9ADCY5ADCY8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229510-B1 | SULFINYL AND SULFONYL SUBSTITUTED-3-BENZAZEPINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-06 | — | — | EP | claimed |
| US-4824839-A | Sulfinyl and sulfonyl substituted 2,3,4,5 tetrahydro-1H-3-benzazepines and their use in treating gastrointestinal motility disorders | SMITHKLINE BECKMAN CORPORATION (US) | 1989-04-25 | — | — | US | claimed |
| EP-0229510-A1 | Sulfinyl and sulfonyl substituted-3-benzazepines | SMITHKLINE BEECHAM CORPORATION (US) | 1987-07-22 | — | — | EP | claimed |
| US-4659706-A | Sulfinyl and sulfonyl substituted 3-benzazepines | SMITHKLINE BECKMAN CORPORATION (US) | 1987-04-21 | — | — | US | claimed |
| WO-1993000094-A2 | USE OF TETRAHYDROBENZAZEPINE DERIVATIVES FOR THE TREATMENT OF PORTAL HYPERTENSION AND MIGRAINE | SMITHKLINE BEECHAM PLC (GB) | 1993-01-07 | — | — | WO | disclosed |
| EP-0229510-B1 | SULFINYL AND SULFONYL SUBSTITUTED-3-BENZAZEPINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-06 | — | — | EP | disclosed |
| US-4824839-A | Sulfinyl and sulfonyl substituted 2,3,4,5 tetrahydro-1H-3-benzazepines and their use in treating gastrointestinal motility disorders | SMITHKLINE BECKMAN CORPORATION (US) | 1989-04-25 | — | — | US | disclosed |
| WO-1988007858-A1 | SULFINYL AND SULFONYL SUBSTITUTED 3-BENZAZEPINES | SMITHKLINE BECKMAN CORPORATION (US) | 1988-10-20 | — | — | WO | disclosed |
| EP-0244088-A2 | 1-Phenyl-3-benzazepine compounds and medicaments containing these compounds for treating gastrointestinal motility disorders | SMITHKLINE BEECHAM CORPORATION (US) | 1987-11-04 | — | — | EP | disclosed |
| EP-0229510-A1 | Sulfinyl and sulfonyl substituted-3-benzazepines | SMITHKLINE BEECHAM CORPORATION (US) | 1987-07-22 | — | — | EP | disclosed |
| US-4659706-A | Sulfinyl and sulfonyl substituted 3-benzazepines | SMITHKLINE BECKMAN CORPORATION (US) | 1987-04-21 | — | — | US | disclosed |
| US-4659706-A | Sulfinyl and sulfonyl substituted 3-benzazepines | SMITHKLINE BECKMAN CORPORATION (US) | 1987-04-21 | — | — | US | disclosed |