Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 9/20 | 0.63 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.63 |
| ▸ | CCR3 | P51677 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972912 | 0.86 | GRIN2B (0.83) | GRIN2BGRIN1CCR3ALDH1A1HRH3 | |
| SCHEMBL7099313 | 0.84 | GRIN2B (0.57) | GRIN2BGRIN1CCR3MEN1KMT2A | |
| SCHEMBL9534906 | 0.81 | GRIN2B (0.64) | GRIN2BGRIN1CCR3ALDH1A1HRH3 | |
| SCHEMBL10548102 | 0.80 | THRB (0.64) | GRIN2BGRIN1MEN1KMT2A | |
| SCHEMBL5242115 | 0.79 | GRIN1 (0.85) | GRIN2BGRIN1GAA | |
| SCHEMBL5237195 | 0.79 | GRIN1 (0.84) | GRIN2BGRIN1CCR3GAA | |
| SCHEMBL10552369 | 0.78 | THRB (0.59) | GRIN2BGRIN1CCR3MEN1KMT2A | |
| SCHEMBL1388535 | 0.77 | GRIN2B (1.00) | GRIN2BGRIN1CCR3HTT | |
| SCHEMBL5241787 | 0.77 | GRIN2B (0.84) | GRIN2BGRIN1 | |
| SCHEMBL5239708 | 0.76 | GRIN1 (0.71) | GRIN2BGRIN1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |