Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 7/20 | 0.64 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.54 |
| ▸ | CCR3 | P51677 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012695 | 0.92 | GRIN2B (0.77) | GRIN2BGRIN1HRH3CCR3ALDH1A1 | |
| SCHEMBL7972912 | 0.87 | GRIN2B (0.83) | GRIN2BGRIN1HRH3CCR3ALDH1A1 | |
| SCHEMBL9537890 | 0.81 | GRIN2B (0.63) | GRIN2BGRIN1HRH3CCR3ALDH1A1 | |
| SCHEMBL1388535 | 0.78 | GRIN2B (1.00) | GRIN2BGRIN1CCR3HTTIDO1 | |
| SCHEMBL8628385 | 0.77 | AAK1 (0.59) | GRIN2BGRIN1IDO1 | |
| SCHEMBL10548102 | 0.76 | THRB (0.64) | GRIN2BGRIN1DRD4 | |
| SCHEMBL7073777 | 0.76 | GRIN2B (0.52) | GRIN2BGRIN1ROCK2ROCK1IDO1 | |
| SCHEMBL10552369 | 0.74 | THRB (0.59) | GRIN2BGRIN1CCR3DRD4 | |
| SCHEMBL5237195 | 0.73 | GRIN1 (0.84) | GRIN2BGRIN1CCR3GAAGRIN2A | |
| SCHEMBL7241045 | 0.73 | GRIN1 (0.65) | GRIN2BGRIN1HRH3CCR3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |