Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 4/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | IDH1 | O75874 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537279 | 0.86 | ADORA3 (0.43) | BRD4HSD17B3KDM4EHTR2AHTR2C | |
| SCHEMBL9535647 | 0.82 | ADORA3 (0.45) | BRD4MAPTHTR2AHTR2C | |
| SCHEMBL9535510 | 0.81 | BRD4 (0.37) | BRD4HSD17B3HTR2AHTR2C | |
| SCHEMBL9540686 | 0.79 | HTR2A (0.37) | AVPR1AHSD17B3KDM4EHTR2AHTR2C | |
| SCHEMBL9535516 | 0.76 | PTK2 (0.34) | HTR2AHTR2C | |
| SCHEMBL9537240 | 0.75 | PSEN1 (0.47) | AVPR1ABRD4HSD17B3MAPTALDH1A1 | |
| SCHEMBL9538216 | 0.75 | PSEN1 (0.37) | AVPR1AMAPTALDH1A1RAB9AHTR2A | |
| SCHEMBL2704303 | 0.75 | AVPR1A (0.42) | AVPR1AIDH1 | |
| SCHEMBL9538692 | 0.74 | ADORA3 (0.42) | HSD17B3KDM4ERAB9ANOTUM | |
| SCHEMBL9538271 | 0.73 | ADORA3 (0.40) | BRD4HSD17B3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0180352-B1 | BENZENE-FUSED HETEROCYCLIC COMPOUND | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-26 | — | — | EP | disclosed |
| US-4767780-A | SUBSTITUTED 1,4-DIHYDRO-(1)-BENZOPYRANO(4,3-C)PYRAZOLES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-08-30 | — | — | US | disclosed |
| US-4675324-A | Substituted pyrazolo [4,3-c]pyridines and their use as uricosuric, diuretic and anti-hypertensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-23 | — | — | US | disclosed |
| EP-0180352-A2 | Benzene-fused heterocyclic compound | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-07 | — | — | EP | disclosed |