Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535516 | 0.79 | PTK2 (0.34) | PTK2GABRG2GABRB3GABRA5LMNA | |
| SCHEMBL9540819 | 0.75 | PSEN1 (0.64) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9537279 | 0.75 | ADORA3 (0.43) | GABRG2GABRB3GABRA5HTR2AHTR2C | |
| SCHEMBL9537919 | 0.75 | AVPR1A (0.40) | ALDH1A1RAB9AAVPR1AHTR2AHTR2C | |
| SCHEMBL9535647 | 0.73 | ADORA3 (0.45) | GABRG2GABRB3GABRA5LMNAHTR2A | |
| SCHEMBL9535510 | 0.72 | BRD4 (0.37) | GABRG2GABRB3GABRA5HTR2AHTR2C | |
| SCHEMBL9540686 | 0.71 | HTR2A (0.37) | AVPR1AGABRG2GABRB3GABRA5HTR2A | |
| SCHEMBL9537880 | 0.67 | MAPT (0.51) | ALDH1A1MAPT | |
| SCHEMBL9537170 | 0.67 | DRD4 (0.36) | LMNAHTR2AHTR2CGABRA1GABRA2 | |
| SCHEMBL10368994 | 0.67 | MMP12 (0.57) | LMNAHTR2AHTR2CGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0180352-B1 | BENZENE-FUSED HETEROCYCLIC COMPOUND | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-26 | — | — | EP | disclosed |
| US-4767780-A | SUBSTITUTED 1,4-DIHYDRO-(1)-BENZOPYRANO(4,3-C)PYRAZOLES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-08-30 | — | — | US | disclosed |
| US-4675324-A | Substituted pyrazolo [4,3-c]pyridines and their use as uricosuric, diuretic and anti-hypertensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-23 | — | — | US | disclosed |
| EP-0180352-A2 | Benzene-fused heterocyclic compound | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-07 | — | — | EP | disclosed |