Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL506708 | 0.77 | NPC1 (0.64) | LMNAHPGDSMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL20266307 | 0.77 | ALDH1A1 (1.00) | ALDH1A1LMNAHPGDSMN1; SMN2TSHR | |
| SCHEMBL7798331 | 0.77 | HPGD (1.00) | ALDH1A1HPGDSMN1; SMN2TSHRCYP1A2 | |
| SCHEMBL28502347 | 0.75 | KDM4E (0.62) | LMNAHPGDSMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL12443351 | 0.75 | KMT2A (0.68) | ALDH1A1LMNAHPGDSMN1; SMN2TSHR | |
| SCHEMBL3456761 | 0.74 | ALDH1A1 (0.66) | ALDH1A1LMNAHPGDSMN1; SMN2TSHR | |
| SCHEMBL8063553 | 0.73 | ALDH1A1 (0.62) | ALDH1A1LMNAHPGDSMN1; SMN2TSHR | |
| SCHEMBL14698469 | 0.73 | HTT (0.49) | ALDH1A1LMNAHPGDSMN1; SMN2TSHR | |
| SCHEMBL8062369 | 0.72 | ALDH1A1 (0.61) | ALDH1A1LMNAHPGDSMN1; SMN2TSHR | |
| SCHEMBL6432446 | 0.72 | MITF (0.68) | ALDH1A1LMNAHPGDSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417745-B1 | Heteroaryl substituted imidazo [4,5-c] pyridines | SEARLE & CO (US) | 1993-11-03 | — | — | EP | disclosed |
| EP-0417745-A2 | Heteroaryl substituted imidazo [4,5-c] pyridines | G.D. Searle & Co. (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4990518-A | Platelet activating factor | G. D. SEARLE & CO. (US) | 1991-02-05 | — | — | US | disclosed |