Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.77 |
| ▸ | BLM | P54132 | 1/20 | 0.77 |
| ▸ | VCP | P55072 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.77 |
| ▸ | HPRT1 | P00492 | 14/20 | 0.71 |
| ▸ | PNP | P00491 | 6/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8990305 | 0.99 | MEN1 (0.78) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| SCHEMBL8990372 | 0.99 | MEN1 (0.78) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| SCHEMBL9537422 | 0.99 | MEN1 (0.78) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| Ganciclovir SCHEMBL634653 | 0.92 | BLM (0.91) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| Ganciclovir SCHEMBL6047042 | 0.92 | BLM (0.91) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| Ganciclovir SCHEMBL1061493 | 0.92 | BLM (0.91) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| SCHEMBL9538377 | 0.89 | BLM (0.75) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| SCHEMBL9538298 | 0.88 | MEN1 (0.64) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| Ganciclovir SCHEMBL3033 | 0.87 | BLM (1.00) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| Ganciclovir SCHEMBL2160505 | 0.87 | BLM (1.00) | MEN1ALDH1A1LMNACYP3A4NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993006112-A1 | THERAPEUTIC NUCLEOSIDES | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-04-01 | — | — | WO | claimed |