Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | EDNRA | P25101 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9146455 | 0.91 | MEN1 (0.58) | MEN1KMT2AKDM4EMAPTHTT | |
| SCHEMBL10758715 | 0.89 | KDM4E (0.58) | MEN1KMT2AKDM4EMAPK8MAPT | |
| SCHEMBL9536907 | 0.89 | KDM4E (0.54) | MEN1KMT2AKDM4EMAPK8MAPT | |
| SCHEMBL10652966 | 0.89 | KDM4E (0.51) | MEN1KMT2AKDM4EMAPK8MAPT | |
| SCHEMBL9143441 | 0.89 | MEN1 (0.54) | MEN1KMT2AKDM4EMAPK8MAPT | |
| SCHEMBL9538611 | 0.88 | MAPK8 (0.48) | MEN1KMT2AKDM4EMAPK8MAPT | |
| SCHEMBL9538371 | 0.88 | MAPK8 (0.48) | MEN1KMT2AKDM4EMAPK8MAPT | |
| SCHEMBL10464433 | 0.86 | MAPK8 (0.57) | KMT2AKDM4EMAPK8MAPTSMN1; SMN2 | |
| SCHEMBL9537683 | 0.85 | MAPT (0.60) | MEN1KMT2AKDM4EMAPTHTT | |
| SCHEMBL9534704 | 0.84 | KDM4E (0.53) | MEN1KMT2AKDM4EMAPK8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |