Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 2/20 | 0.60 |
| ▸ | EDNRA | P25101 | 2/20 | 0.60 |
| ▸ | PLA2G2A | P14555 | 17/20 | 0.57 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535154 | 0.82 | PLA2G2A (0.46) | EDNRBEDNRAPLA2G2APLA2G1B | |
| SCHEMBL9540898 | 0.81 | KDM4E (0.57) | EDNRBEDNRAKMT2A | |
| SCHEMBL9534543 | 0.80 | PLA2G2A (0.56) | EDNRBEDNRAPLA2G2APLA2G1BTSHR | |
| SCHEMBL9537603 | 0.77 | PLA2G2A (0.55) | EDNRBEDNRAPLA2G2APLA2G1BTSHR | |
| SCHEMBL336644 | 0.76 | PLA2G2A (0.61) | PLA2G2APLA2G1BTSHRMAPK1KMT2A | |
| SCHEMBL21465533 | 0.76 | MEN1 (0.82) | EDNRBEDNRATSHRKMT2A | |
| SCHEMBL23759991 | 0.76 | MEN1 (0.74) | EDNRBEDNRAPLA2G2ATSHRKMT2A | |
| SCHEMBL30742798 | 0.76 | MEN1 (0.74) | EDNRBEDNRAPLA2G2ATSHRKMT2A | |
| SCHEMBL6632096 | 0.75 | EDNRA (1.00) | EDNRBEDNRATSHRKMT2A | |
| SCHEMBL4885587 | 0.75 | PLA2G10 (0.64) | EDNRBEDNRAPLA2G2APLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |