Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 14/20 | 0.56 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.53 |
| ▸ | EDNRB | P24530 | 2/20 | 0.52 |
| ▸ | EDNRA | P25101 | 2/20 | 0.52 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | YWHAH | Q04917 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537603 | 0.89 | PLA2G2A (0.55) | PLA2G2APLA2G1BEDNRBEDNRATP53 | |
| SCHEMBL9535566 | 0.81 | KDM4E (0.56) | EDNRBEDNRATP53KMT2A | |
| SCHEMBL9538437 | 0.80 | EDNRB (0.60) | PLA2G2APLA2G1BEDNRBEDNRATSHR | |
| SCHEMBL4885587 | 0.76 | PLA2G10 (0.64) | PLA2G2APLA2G1BEDNRBEDNRAPLA2G10 | |
| SCHEMBL336644 | 0.76 | PLA2G2A (0.61) | PLA2G2APLA2G1BTSHRMAPK1KMT2A | |
| SCHEMBL4363430 | 0.74 | PLA2G2A (0.79) | PLA2G2APLA2G1BTSHRMAPK1KMT2A | |
| SCHEMBL29952730 | 0.73 | MAPT (0.62) | PLA2G2AEDNRBEDNRAPLA2G10TP53 | |
| SCHEMBL9142952 | 0.73 | L3MBTL1 (0.47) | TP53KMT2A | |
| SCHEMBL337183 | 0.72 | PLA2G2A (0.59) | PLA2G2APLA2G1BTSHRKMT2A | |
| SCHEMBL19321312 | 0.71 | EDNRB (0.53) | PLA2G2APLA2G1BEDNRBEDNRATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |