Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 10/20 | 0.64 |
| ▸ | CTSL | P07711 | 2/20 | 0.56 |
| ▸ | CTSS | P25774 | 1/20 | 0.56 |
| ▸ | CTSK | P43235 | 3/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 7/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535447 | 0.89 | SIRT2 (0.59) | SIRT2CTSLCTSSCTSKSIRT1 | |
| SCHEMBL9535457 | 0.89 | SIRT2 (0.59) | SIRT2CTSLCTSSCTSKSIRT1 | |
| SCHEMBL11153005 | 0.86 | CTSL (0.61) | SIRT2CTSLCTSKSMN1; SMN2 | |
| SCHEMBL24853552 | 0.86 | CTSK (0.63) | SIRT2CTSLCTSSCTSK | |
| SCHEMBL29248976 | 0.86 | CTSK (0.63) | SIRT2CTSLCTSSCTSK | |
| SCHEMBL14213349 | 0.85 | SIRT2 (0.70) | SIRT2CTSLCTSSSIRT1SIRT3 | |
| SCHEMBL12243918 | 0.85 | SIRT2 (0.70) | SIRT2CTSLCTSSSIRT1SIRT3 | |
| SCHEMBL9537091 | 0.84 | CTSL (0.58) | SIRT2CTSLCTSSCTSKSMN1; SMN2 | |
| SCHEMBL9537095 | 0.84 | CTSL (0.58) | SIRT2CTSLCTSSCTSKSMN1; SMN2 | |
| SCHEMBL20211867 | 0.84 | CTSL (0.61) | SIRT2CTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0182262-B1 | NONA AND DECAPEPTIDE ANALOGS OF LHRH USEFUL AS LHRH ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-01-20 | — | — | EP | disclosed |
| EP-0097031-B1 | NONAPEPTIDE AND DECAPEPTIDE ANALOGS OF LHRH USEFUL AS LHRH ANTAGONISTS, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | SYNTEX (U.S.A.) INC. (US) | 1988-09-21 | — | — | EP | disclosed |
| US-4690916-A | ANTIFERTILITY AGENTS; HALO-SUBSTITUTED GUANADINO AMINO ACYL RESIDUE COMPONENT | SYNTEX (U.S.A.) INC. (US) | 1987-09-01 | — | — | US | disclosed |
| EP-0182262-A2 | Nona and decapeptide analogs of LHRH useful as LHRH antagonists | SYNTEX (U.S.A.) INC. (US) | 1986-05-28 | — | — | EP | disclosed |
| US-4581169-A | Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH antagonists | SYNTEX (U.S.A.) INC. (US) | 1986-04-08 | — | — | US | disclosed |
| US-4481190-A | LUTEINIZING HORMONE RELEASING HORMONE | SYNTEX (U.S.A.) INC. (US) | 1984-11-06 | — | — | US | disclosed |
| EP-0097031-A2 | Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists, their preparation and compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1983-12-28 | — | — | EP | disclosed |