Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | EDNRA | P25101 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | EDNRB | P24530 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760065 | 0.83 | JAK2 (0.44) | KDM4EEDNRAMAPTMEN1KMT2A | |
| SCHEMBL22760471 | 0.83 | FOLH1 (0.44) | KDM4EEDNRAMAPTHTTMEN1 | |
| SCHEMBL22760442 | 0.83 | EDNRA (0.50) | KDM4EEDNRAMAPTMEN1KMT2A | |
| SCHEMBL22747838 | 0.82 | NOTUM (0.42) | KDM4EEDNRAMEN1KMT2AALDH1A1 | |
| SCHEMBL22760067 | 0.82 | EDNRA (0.41) | KDM4EEDNRAMAPTHTTMEN1 | |
| SCHEMBL9535709 | 0.81 | KDM4E (0.42) | KDM4EEDNRAMAPTHTTMEN1 | |
| SCHEMBL10761647 | 0.80 | KDM4E (0.64) | KDM4EEDNRAMAPTHTTMEN1 | |
| SCHEMBL9146455 | 0.80 | MEN1 (0.58) | KDM4EEDNRAMAPTHTTMEN1 | |
| SCHEMBL22747888 | 0.80 | FOLH1 (0.42) | EDNRAMAPTALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL22760346 | 0.80 | FOLH1 (0.45) | EDNRAMAPTALDH1A1FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |