Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.39 |
| ▸ | RPA1 | P27694 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | EDNRB | P24530 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | USP14 | P54578 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22747838 | 0.89 | NOTUM (0.42) | EDNRAMEN1KMT2AMAPK8ALDH1A1 | |
| SCHEMBL22760375 | 0.87 | NOTUM (0.37) | MEN1KMT2ARPA1MAPTALDH1A1 | |
| SCHEMBL22760346 | 0.87 | FOLH1 (0.45) | EDNRAMAPK8MAPTALDH1A1FOLH1 | |
| SCHEMBL22760073 | 0.86 | CENPE (0.39) | MEN1KMT2APPARGMAPK8FOLH1 | |
| SCHEMBL22760373 | 0.83 | FOLH1 (0.36) | PPARGMAPK8RPA1KDM4EFOLH1 | |
| SCHEMBL22760426 | 0.82 | EDNRA (0.39) | EDNRAMEN1KMT2APPARGRPA1 | |
| SCHEMBL9538849 | 0.82 | KDM4E (0.57) | EDNRAMEN1KMT2APPARGMAPT | |
| SCHEMBL22760140 | 0.82 | NOTUM (0.41) | EDNRAMEN1KMT2AMAPK8ALDH1A1 | |
| SCHEMBL22760374 | 0.81 | HTT (0.33) | HTTFOLH1 | |
| SCHEMBL22747843 | 0.81 | MAPK8 (0.40) | EDNRAMEN1KMT2APPARGMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |