Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.41 |
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL9537204 | 0.89 | BCHE (0.45) | KDM4EALDH1A1HPGDBCHESMN1; SMN2 | |
| Salicylic Acid SCHEMBL9536737 | 0.88 | BCHE (0.44) | KDM4EALDH1A1HPGDBCHESMN1; SMN2 | |
| SCHEMBL9540615 | 0.87 | SIGMAR1 (0.48) | BCHESIGMAR1OPRM1OPRD1OPRK1 | |
| Salicylic Acid SCHEMBL9541177 | 0.86 | BCHE (0.43) | KDM4EALDH1A1HPGDBCHESMN1; SMN2 | |
| Salicylic Acid SCHEMBL9538265 | 0.86 | BCHE (0.48) | BCHEACHEOPRM1OPRD1OPRK1 | |
| SCHEMBL9538866 | 0.85 | BCHE (0.41) | KDM4EALDH1A1HPGDBCHESMN1; SMN2 | |
| SCHEMBL2455194 | 0.77 | BCHE (0.48) | KDM4EBCHEACHEHIF1AHSD17B10 | |
| SCHEMBL2455192 | 0.77 | BCHE (0.48) | KDM4EBCHEACHEHIF1AHSD17B10 | |
| SCHEMBL9539147 | 0.76 | OPRM1 (0.44) | KDM4EHIF1AHSD17B10SIGMAR1OPRM1 | |
| SCHEMBL2459774 | 0.76 | OPRM1 (0.53) | BCHEACHEOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5187165-A | Eseroline derivatives; cholinergic agents; antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-02-16 | — | — | US | disclosed |