Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12970077 | 0.80 | KMT2A (0.42) | BACE1KDM4EPDGFRBPDGFRAKMT2A | |
| SCHEMBL26608198 | 0.80 | BACE1 (0.40) | BACE1KDM4EPDGFRBPDGFRAKMT2A | |
| SCHEMBL3579340 | 0.77 | ALDH1A1 (0.62) | BACE1KDM4EPDGFRBPDGFRAKMT2A | |
| SCHEMBL3578871 | 0.77 | KMT2A (0.65) | BACE1KDM4EPDGFRBPDGFRAKMT2A | |
| SCHEMBL28208080 | 0.77 | NR4A2 (0.44) | BACE1PDGFRBPDGFRAKMT2ANPSR1 | |
| SCHEMBL32662668 | 0.76 | ALDH1A1 (0.66) | BACE1KDM4EKMT2ACYP1A2ALDH1A1 | |
| SCHEMBL6509 | 0.76 | ALDH1A1 (0.66) | BACE1KDM4EKMT2ACYP1A2ALDH1A1 | |
| SCHEMBL12014783 | 0.76 | ALDH1A1 (0.45) | KDM4EPDGFRBPDGFRAKMT2AALDH1A1 | |
| SCHEMBL14047370 | 0.76 | KMT2A (0.50) | BACE1KDM4EKMT2ANPSR1ALDH1A1 | |
| SCHEMBL27866926 | 0.76 | BACE1 (0.37) | BACE1KDM4EPDGFRBPDGFRAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0379413-B1 | 1,8-Benzonaphthyridine derivatives, their production and compositions containing them | BELLON LABOR SA ROGER (FR) | 1993-12-22 | — | — | EP | disclosed |
| EP-0379413-A1 | 1,8-Benzonaphthyridine derivatives, their production and compositions containing them | Société anonyme dite: LABORATOIRE ROGER BELLON (FR) | 1990-07-25 | — | — | EP | disclosed |