Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.34 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6929230 | 0.97 | SNCA (0.43) | SNCATTRHTR2ASLC6A4LPAR1 | |
| Bromide SCHEMBL7929116 | 0.83 | HIF1A (0.38) | TTRHRH1 | |
| Bromide SCHEMBL5440664 | 0.82 | SNCA (0.45) | SNCA | |
| Bromide SCHEMBL9804327 | 0.81 | FDFT1 (0.42) | TTRLPAR1LPAR5 | |
| Hydrochloric Acid SCHEMBL5355794 | 0.77 | SNCA (0.55) | SNCALTA4H | |
| SCHEMBL13888115 | 0.76 | TTR (0.47) | TTRHTR2ASLC6A4LPAR1LPAR5 | |
| SCHEMBL10547891 | 0.76 | TTR (0.44) | TTRHTR2ASLC6A4LPAR1LPAR5 | |
| SCHEMBL10743171 | 0.76 | TTR (0.44) | TTRHTR2ASLC6A4LPAR1LPAR5 | |
| SCHEMBL3710992 | 0.76 | TTR (0.44) | TTRHTR2ASLC6A4LPAR1LPAR5 | |
| Hydrochloric Acid SCHEMBL9643089 | 0.76 | FDFT1 (0.47) | SNCALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5223536-A | Pyrethroid-like pesticides | FMC CORPORATION (US) | 1993-06-29 | — | — | US | disclosed |
| WO-1993001715-A1 | 1,4-DIARYL-1-CYCLOPROPYL-4-SUBSTITUTED BUTANES AS INSECTICIDES AND ACARICIDES | FMC CORPORATION (US) | 1993-02-04 | — | — | WO | disclosed |
| EP-0357610-B1 | INSECTICIDAL CYCLOPROPYL-SUBSTITUTED DI(ARYL) COMPOUNDS | FMC Corporation (US) | 1992-09-16 | — | — | EP | disclosed |
| US-4975451-A | Insecticidal cyclopropyl di(aryl) 2-butenes | FMC CORPORATION (US) | 1990-12-04 | — | — | US | disclosed |
| EP-0357610-A1 | INSECTICIDAL CYCLOPROPYL-SUBSTITUTED DI(ARYL) COMPOUNDS. | FMC CORP (US) | 1990-03-14 | — | — | EP | disclosed |
| US-4808762-A | Insecticidal cyclopropyl-substituted di(aryl) compounds | FMC CORPORATION (US) | 1989-02-28 | — | — | US | disclosed |
| WO-1988008416-A1 | INSECTICIDAL CYCLOPROPYL-SUBSTITUTED DI(ARYL) COMPOUNDS | FMC CORPORATION (US) | 1988-11-03 | — | — | WO | disclosed |