Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9539776 | 1.00 | MAPT (0.42) | MAPTNR4A2KCNH2TP53OPRM1 | |
| Oxalic Acid SCHEMBL9535461 | 0.89 | MAPT (0.43) | MAPTNR4A2KCNH2TP53OPRM1 | |
| Oxalic Acid SCHEMBL9535458 | 0.89 | MAPT (0.43) | MAPTNR4A2KCNH2TP53OPRM1 | |
| Oxalic Acid SCHEMBL9538445 | 0.83 | HRH1 (0.44) | MAPTKCNH2OPRM1OPRD1OPRK1 | |
| Oxalic Acid SCHEMBL9538448 | 0.83 | HRH1 (0.44) | MAPTKCNH2OPRM1OPRD1OPRK1 | |
| SCHEMBL9536526 | 0.82 | NR4A2 (0.47) | MAPTNR4A2KCNH2TP53OPRM1 | |
| SCHEMBL10383260 | 0.82 | TP53 (0.46) | MAPTNR4A2KCNH2TP53CYP1A2 | |
| SCHEMBL9536525 | 0.82 | MAPT (0.42) | MAPTKCNH2TP53OPRM1OPRD1 | |
| SCHEMBL9538214 | 0.82 | NR4A2 (0.42) | MAPTNR4A2KCNH2TP53OPRM1 | |
| Hydrochloric Acid SCHEMBL9536739 | 0.81 | NR4A2 (0.41) | MAPTNR4A2KCNH2TP53OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282133-B1 | 1-ALKYL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-07-28 | — | — | EP | disclosed |
| US-4943580-A | ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |
| EP-0282133-A2 | 1-alkyl substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-09-14 | — | — | EP | disclosed |