Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | EEF2K | O00418 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9540145 | 0.76 | BCL2 (0.47) | SMN1; SMN2BCL2POLBL3MBTL1SCN5A | |
| SCHEMBL9540122 | 0.71 | HTR2A (0.43) | SMN1; SMN2BCL2POLBL3MBTL1SCN5A | |
| SCHEMBL12267924 | 0.69 | SCN5A (0.65) | SMN1; SMN2BCL2SCN5ASCN9A | |
| SCHEMBL5159643 | 0.68 | SIGMAR1 (0.62) | LMNASMN1; SMN2BCL2KDM4E | |
| Hydrochloric Acid SCHEMBL10512222 | 0.67 | CHRM4 (0.62) | LMNASMN1; SMN2BCL2KDM4EMEN1 | |
| SCHEMBL10083659 | 0.66 | SMN1; SMN2 (0.59) | CDC7EEF2KPLK4AURKAPDPK1 | |
| SCHEMBL14272057 | 0.66 | SMN1; SMN2 (0.59) | CDC7EEF2KPLK4AURKAPDPK1 | |
| SCHEMBL10083638 | 0.66 | SMN1; SMN2 (0.59) | CDC7EEF2KPLK4AURKAPDPK1 | |
| SCHEMBL6096534 | 0.65 | GAA (0.73) | LMNASMN1; SMN2MAPTPOLBALDH1A1 | |
| SCHEMBL11620037 | 0.64 | HTR2A (0.47) | LMNASMN1; SMN2BCL2L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0530994-A1 | Quinazoline derivatives as inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| WO-1993004047-A1 | QUINAZOLINE DERIVATIVES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO., INC. (US) | 1993-03-04 | — | — | WO | disclosed |