Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 6/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TACR2 | P21452 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9537718 | 0.86 | TP53 (0.52) | RAB9AHRH1CYP2D6KCNH2TP53 | |
| SCHEMBL9537249 | 0.86 | SCN9A (0.53) | RAB9AHRH1CYP2D6KCNH2TP53 | |
| SCHEMBL9540172 | 0.83 | TP53 (0.53) | RAB9AHRH1CYP2D6KCNH2TP53 | |
| SCHEMBL9536543 | 0.82 | SSTR5 (0.66) | RAB9AHRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL9537554 | 0.81 | HRH1 (0.63) | RAB9AHRH1CYP2D6KCNH2TP53 | |
| SCHEMBL9537797 | 0.81 | RAB9A (0.57) | RAB9AHRH1CYP2D6KCNH2CHRM1 | |
| Oxalic Acid SCHEMBL10547004 | 0.80 | TP53 (0.53) | RAB9AHRH1CYP2D6KCNH2TP53 | |
| Oxalic Acid SCHEMBL9536322 | 0.80 | TP53 (0.53) | RAB9AHRH1CYP2D6KCNH2TP53 | |
| Hydrochloric Acid SCHEMBL9539517 | 0.80 | HRH1 (0.62) | RAB9AHRH1CYP2D6KCNH2TP53 | |
| SCHEMBL10550102 | 0.80 | GNRHR (0.51) | RAB9AHRH1CYP2D6KCNH2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |