Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537955 | 0.88 | NOTUM (0.47) | POLBMAPTCYP11B1CYP11B2TP53 | |
| SCHEMBL9539028 | 0.78 | KDM4E (0.40) | POLBMAPTTP53NOTUMKDM4E | |
| SCHEMBL9535907 | 0.74 | NOTUM (0.47) | POLBMAPTCYP11B1CYP11B2TP53 | |
| SCHEMBL9540984 | 0.72 | CYP11B1 (0.44) | POLBMAPTCYP11B1CYP11B2TP53 | |
| SCHEMBL9537808 | 0.70 | TP53 (0.40) | POLBMAPTCYP11B1CYP11B2TP53 | |
| SCHEMBL10869086 | 0.70 | LMNA (0.55) | POLBMAPTCYP11B1CYP11B2TP53 | |
| SCHEMBL9540553 | 0.69 | MAPT (0.47) | POLBMAPTCYP11B1CYP11B2TP53 | |
| SCHEMBL9537029 | 0.69 | CYP11B1 (0.43) | POLBMAPTCYP11B1CYP11B2TP53 | |
| SCHEMBL11136938 | 0.69 | NOTUM (0.47) | POLBCYP11B1CYP11B2TP53TSHR | |
| SCHEMBL9536870 | 0.68 | F10 (0.41) | POLBMAPTCYP11B1CYP11B2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0180352-B1 | BENZENE-FUSED HETEROCYCLIC COMPOUND | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-26 | — | — | EP | disclosed |
| US-4767780-A | SUBSTITUTED 1,4-DIHYDRO-(1)-BENZOPYRANO(4,3-C)PYRAZOLES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-08-30 | — | — | US | disclosed |
| US-4675324-A | Substituted pyrazolo [4,3-c]pyridines and their use as uricosuric, diuretic and anti-hypertensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-06-23 | — | — | US | disclosed |
| EP-0180352-A2 | Benzene-fused heterocyclic compound | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-07 | — | — | EP | disclosed |