Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.70 |
| ▸ | DRD2 | P14416 | 1/20 | 0.70 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.70 |
| ▸ | HTR1B | P28222 | 1/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.70 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.70 |
| ▸ | DRD3 | P35462 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7648536 | 0.99 | HTR1A (0.69) | HTR1ADRD2ADRA1DHTR1BADRA1A | |
| SCHEMBL5814914 | 0.83 | HTR1A (0.75) | HTR1ADRD2ADRA1DHTR1BADRA1A | |
| Hydrochloric Acid SCHEMBL7572442 | 0.83 | HTR1A (0.54) | HTR1ADRD2ADRA1DHTR1BADRA1A | |
| Mazapertine SCHEMBL636631 | 0.83 | HTR1A (1.00) | HTR1ADRD2ADRA1DHTR1BADRA1A | |
| SCHEMBL13533242 | 0.83 | HTR1A (1.00) | HTR1ADRD2ADRA1DHTR1BADRA1A | |
| Mazapertine SCHEMBL7643633 | 0.82 | HTR1A (0.98) | HTR1ADRD2ADRA1DHTR1BADRA1A | |
| Hydrochloric Acid SCHEMBL7644692 | 0.82 | HTR1A (0.98) | HTR1ADRD2ADRA1DHTR1BADRA1A | |
| SCHEMBL5899207 | 0.80 | HTR1A (0.62) | HTR1ADRD2ADRA1DHTR1BADRA1A | |
| Mazapertine SCHEMBL1649526 | 0.79 | HTR1A (0.91) | HTR1ADRD2ADRA1DHTR1BADRA1A | |
| Mazapertine SCHEMBL6013382 | 0.79 | HTR1A (0.91) | HTR1ADRD2ADRA1DHTR1BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563345-A1 | NOVEL 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES | MCNEILAB, INC. (US) | 1993-10-06 | — | — | EP | claimed |
| EP-0562049-A1 | NOVEL 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES | MCNEILAB, INC. (US) | 1993-09-29 | — | — | EP | claimed |
| WO-1993004682-A1 | NOVEL 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES | MCNEILAB, INC. (US) | 1993-03-18 | — | — | WO | claimed |
| WO-1993004684-A1 | NOVEL 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES | MCNEILAB, INC. (US) | 1993-03-18 | — | — | WO | claimed |