Mazapertine

Mazapertine

SCHEMBL636631

CC(C)Oc1ccccc1N1CCN(Cc2cccc(C(=O)N3CCCCC3)c2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 2/20 1.00
ADRA1D P25100 2/20 1.00
ADRA1A P35348 2/20 1.00
ADRA1B P35368 2/20 1.00
DRD2 P14416 1/20 1.00
HTR1B P28222 1/20 1.00
DRD3 P35462 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13533242 1.00 HTR1A (1.00) HTR1AADRA1DADRA1AADRA1BDRD2
Hydrochloric Acid SCHEMBL7644692 0.99 HTR1A (0.98) HTR1AADRA1DADRA1AADRA1BDRD2
Mazapertine SCHEMBL7643633 0.99 HTR1A (0.98) HTR1AADRA1DADRA1AADRA1BDRD2
Mazapertine SCHEMBL6013382 0.95 HTR1A (0.91) HTR1AADRA1DADRA1AADRA1BDRD2
Mazapertine SCHEMBL1649526 0.95 HTR1A (0.91) HTR1AADRA1DADRA1AADRA1BDRD2
Mazapertine SCHEMBL120658 0.95 HTR1A (0.91) HTR1AADRA1DADRA1AADRA1BDRD2
SCHEMBL9540919 0.90 ADRA1D (0.82) HTR1AADRA1DADRA1AADRA1BDRD2
Hydrochloric Acid SCHEMBL7647394 0.89 HTR1A (0.80) HTR1AADRA1DADRA1AADRA1BDRD2
SCHEMBL9539641 0.89 HTR1A (0.80) HTR1AADRA1DADRA1AADRA1BDRD2
SCHEMBL13533236 0.89 HTR1A (0.80) HTR1AADRA1DADRA1AADRA1BDRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 594 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1931320-B1 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL DOSAGE FORM COMPRISING THE SAME FLAMEL IRELAND LTD (IE) 2022-06-15 EP claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
WO-2011126937-A1 TARGETED INTRACELLULAR DELIVERY OF OLIGONUCLEOTIDES VIA CONJUGATION WITH SMALL MOLECULE LIGANDS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2011-10-13 WO claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
US-20100168085-A1 Dopamine and agonists and antagonists thereof for modulation of suppressive activity of CD4+CD25+ regulatory T cells YESA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE (IL) 2010-07-01 US claimed
US-20090220611-A1 Microparticles With Modified Release of At Least One Active Principle and Oral Pharmaceutical Form Comprising Same FLAMEL TECHNOLOGIES, S.A. (FR) 2009-09-03 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
EP-1626703-A2 DOPAMINE AND AGONISTS AND ANTAGONISTS THEREOF FOR MODULATION OF SUPPRESSIVE ACTIVITY OF CD4+CD25+ REGULATORY T CELLS YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2006-02-22 EP claimed
US-20060024365-A1 Novel dosage form VAYA NAVIN 2006-02-02 US claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
EP-1044023-B1 A COVALENT CONJUGATE OF CLOZAPINE WITH A FATTY ACID AND ITS USE FOR TREATING SCHIZOPHRENIA LUITPOLD PHARM INC (US) 2005-05-25 EP claimed
WO-2004103263-A2 DOPAMINE AND AGONISTS AND ANTAGONISTS THEREOF FOR TREATMENT OF NEURODEGENERATIVE DISEASES YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2004-12-02 WO claimed
WO-2004103262-A2 DOPAMINE AND AGONISTS AND ANTAGONISTS THEREOF FOR MODULATION OF SUPPRESSIVE ACTIVITY OF CD4+CD25+ REGULATORY T CELLS YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2004-12-02 WO claimed
EP-0563345-B1 NOVEL 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES MCNEILAB INC (US) 2002-07-03 EP claimed
EP-0562049-A1 NOVEL 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES MCNEILAB, INC. (US) 1993-09-29 EP claimed
WO-1993004684-A1 NOVEL 4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES MCNEILAB, INC. (US) 1993-03-18 WO claimed