Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Acridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.48 |
| ▸ | PPARG | P37231 | 7/20 | 0.48 |
| ▸ | PPARD | Q03181 | 7/20 | 0.48 |
| ▸ | PPARA | Q07869 | 7/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TLR2 | O60603 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | FABP4 | P15090 | 2/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acridine SCHEMBL17892439 | 0.97 | PPARG (0.53) | AKR1B1GPR84PPARGPPARDPPARA | |
| Behenic Acid SCHEMBL31536707 | 0.87 | GPR84 (0.61) | AKR1B1GPR84PPARGPPARDPPARA | |
| Anthracene SCHEMBL9561628 | 0.87 | AKR1B1 (0.61) | AKR1B1GPR84PPARGPPARDPPARA | |
| Stearic Acid SCHEMBL27500805 | 0.85 | GPR84 (0.63) | AKR1B1GPR84PPARGPPARDPPARA | |
| Undecanoate SCHEMBL28709858 | 0.84 | ALDH1A1 (0.60) | GPR84PPARGPPARDPPARAHDAC11 | |
| Acridine SCHEMBL28897857 | 0.83 | ALDH1A1 (0.62) | ALDH1A1MEN1KMT2AGLAMAPT | |
| Acridine SCHEMBL28205217 | 0.83 | ALDH1A1 (0.62) | ALDH1A1GLAMAPTHPGDACHE | |
| Naphthalene SCHEMBL28148380 | 0.83 | AKR1B1 (0.67) | AKR1B1GPR84PPARGPPARDPPARA | |
| Stearic Acid SCHEMBL29123159 | 0.81 | GPR84 (0.68) | AKR1B1GPR84PPARGPPARDPPARA | |
| Myristic Acid SCHEMBL29097493 | 0.81 | GPR84 (0.68) | AKR1B1GPR84PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993014104-A1 | PHOTOCLEAVAGE OF DNA USING ORGANIC OXYRADICALS | EASTMAN KODAK COMPANY (US) | 1993-07-22 | — | — | WO | disclosed |