Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 5/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9543347 | 1.00 | MEN1 (0.44) | MEN1KMT2APOLBL3MBTL1BACE1 | |
| SCHEMBL9544449 | 0.89 | ADRB3 (0.43) | MEN1KMT2APOLBL3MBTL1BACE1 | |
| SCHEMBL9544456 | 0.89 | ADRB3 (0.43) | MEN1KMT2APOLBL3MBTL1BACE1 | |
| SCHEMBL19245779 | 0.83 | TAAR1 (0.46) | MEN1KMT2ABACE1ADRB3KDM4E | |
| SCHEMBL27635276 | 0.83 | GLI1 (0.46) | MEN1KMT2ABACE1ADRB3KDM4E | |
| SCHEMBL12834438 | 0.82 | BACE1 (0.44) | BACE1ADRB3ADRB1KDM4EALDH1A1 | |
| SCHEMBL7122416 | 0.82 | ADRB3 (0.46) | MEN1KMT2ABACE1ADRB3KDM4E | |
| SCHEMBL7694265 | 0.82 | ADRB3 (0.46) | MEN1KMT2ABACE1ADRB3KDM4E | |
| SCHEMBL7122412 | 0.82 | ADRB3 (0.46) | MEN1KMT2ABACE1ADRB3KDM4E | |
| SCHEMBL4472271 | 0.81 | ADRB3 (0.41) | MEN1KMT2ABACE1ADRB3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993010074-A1 | ARYLETHANOLAMINE DERIVATIVES AND THEIR USE AS BETA-3-ADRENOCEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-05-27 | — | — | WO | disclosed |