Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Procaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 5/20 | 0.67 |
| ▸ | SCN2A known ✓ | Q99250 | 5/20 | 0.67 |
| ▸ | SCN3A known ✓ | Q9NY46 | 5/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.97 |
| ▸ | TSHR | P16473 | 5/20 | 0.97 |
| ▸ | MAOA | P21397 | 4/20 | 0.97 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.97 |
| ▸ | HTR3A | P46098 | 2/20 | 0.97 |
| ▸ | BLM | P54132 | 1/20 | 0.94 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.94 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 6/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | DRD3 | P35462 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Procaine SCHEMBL9543344 | 0.98 | BLM (0.97) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL3524 | 0.98 | CYP2D6 (1.00) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL27720 | 0.97 | BLM (1.00) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL6061234 | 0.97 | CYP2D6 (0.97) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL3731588 | 0.97 | BLM (1.00) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL5311049 | 0.97 | BLM (1.00) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL9050778 | 0.97 | CYP2D6 (0.97) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL3422994 | 0.97 | CYP2D6 (0.97) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL6901191 | 0.97 | BLM (1.00) | CYP2D6TSHRMAOAHRH3HTR3A | |
| Procaine SCHEMBL28977033 | 0.97 | CYP2D6 (0.97) | CYP2D6TSHRMAOAHRH3HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119492821-A | Method for rapidly determining multiple anesthetics and metabolites thereof in aquatic products based on QTRAP mass spectrum | 绍兴市食品药品检验研究院 | 2025-02-21 | — | — | CN | claimed |
| CN-117054585-A | Charged surface reversed phase chromatography material method for analysis of glycans modified with amphiphilic strong basic moieties | 沃特世科技公司 | 2023-11-14 | — | — | CN | claimed |
| CN-109154604-B | Charged surface reversed phase chromatography material method for analysis of glycans modified with amphiphilic strong basic moieties | 沃特世科技公司 | 2023-07-21 | — | — | CN | claimed |
| CN-108761062-A | A kind of procainamide immunologic function test reagent and its preparation and detection method | 太原瑞盛生物科技有限公司 | 2018-11-06 | — | — | CN | claimed |
| CN-100485379-C | Identification element of organic phosphorus pesticide and its making method | OCEAN UNIV CHINA (CN) | 2009-05-06 | — | — | CN | claimed |
| CN-1514238-A | Identification element of organic phosphorus pesticide and its making method | 中国海洋大学 | 2004-07-21 | — | — | CN | claimed |
| CN-1147321-C | Threonate possessing of partial basicity and having basic chemical structure medicine in its molecule | 高秉元 | 2004-04-28 | — | — | CN | claimed |
| CN-1194865-A | Threonate possessing of partial basicity and having basic chemical structure medicine in its molecule | GAO BINGYUAN (CN) | 1998-10-07 | — | — | CN | claimed |
| CN-120121749-A | Method for detecting 18 local anesthetics in cosmetics | 苏州市药品检验检测研究中心（苏州市药品不良反应监测中心） | 2025-06-10 | — | — | CN | disclosed |
| CN-119901841-A | Method for simultaneously detecting 25 anesthetics in aquatic products | 重庆市食品药品检验检测研究院 | 2025-04-29 | — | — | CN | disclosed |
| CN-114539408-B | Anti-FLT-1 antibodies for the treatment of Dunaliella muscular dystrophy | 武田药品工业株式会社 | 2025-03-11 | — | — | CN | disclosed |
| CN-119492821-A | Method for rapidly determining multiple anesthetics and metabolites thereof in aquatic products based on QTRAP mass spectrum | 绍兴市食品药品检验研究院 | 2025-02-21 | — | — | CN | disclosed |
| CN-116478045-B | Method for synthesizing nitrobenzoic acid by one-step oxidation of nitrobenzyl chloride | 南昌大学 | 2025-02-07 | — | — | CN | disclosed |
| CN-119303213-A | Drug-coated balloon catheter for body cavities | 优敦力公司 | 2025-01-14 | — | — | CN | disclosed |
| CN-1960631-A | Benzamide and benzoate anti-HIV compounds | SAMARITAN PHARMACEUTICALS INC (US) | 2007-05-09 | — | — | CN | disclosed |
| CN-1514238-A | Identification element of organic phosphorus pesticide and its making method | 中国海洋大学 | 2004-07-21 | — | — | CN | disclosed |
| CN-1147321-C | Threonate possessing of partial basicity and having basic chemical structure medicine in its molecule | 高秉元 | 2004-04-28 | — | — | CN | disclosed |
| CN-1194865-A | Threonate possessing of partial basicity and having basic chemical structure medicine in its molecule | GAO BINGYUAN (CN) | 1998-10-07 | — | — | CN | disclosed |
| US-4470987-A | Process for treatment and prevention of ventricular fibrillation | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1984-09-11 | — | — | US | disclosed |
| US-4271192-A | Process for treatment and prevention of ventricular fibrillation | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1981-06-02 | — | — | US | disclosed |