Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 3/20 | 0.49 |
| ▸ | PRKCG | P05129 | 3/20 | 0.49 |
| ▸ | PRKCB | P05771 | 3/20 | 0.49 |
| ▸ | PRKCA | P17252 | 3/20 | 0.49 |
| ▸ | PRKCH | P24723 | 3/20 | 0.49 |
| ▸ | PRKCI | P41743 | 3/20 | 0.49 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.49 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.49 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.49 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PRKACA | P17612 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9542120 | 0.85 | PRKD3 (0.53) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL9541305 | 0.83 | PRKCG (0.59) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL10754020 | 0.78 | MELK (0.48) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL10983757 | 0.78 | PRKD3 (0.56) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL9541258 | 0.77 | FLT3 (0.62) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL10985713 | 0.77 | PRKD3 (0.60) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL9542795 | 0.76 | PRKCG (0.68) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL11279652 | 0.75 | PRKD3 (0.54) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL7430002 | 0.75 | MELK (0.50) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL5130721 | 0.74 | PRKCG (0.66) | PRKD3PRKCGPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993013072-A1 | 5-ISOQUINOLINESULFONAMIDE DERIVATIVES AS PROTEIN KINASE INHIBITING AGENTS | ITALFARMACO S.P.A. (IT) | 1993-07-08 | — | — | WO | disclosed |