Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.58 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 6/20 | 0.54 |
| ▸ | PRKCG | P05129 | 6/20 | 0.54 |
| ▸ | PRKCB | P05771 | 6/20 | 0.54 |
| ▸ | PRKCA | P17252 | 6/20 | 0.54 |
| ▸ | PRKCH | P24723 | 6/20 | 0.54 |
| ▸ | PRKCI | P41743 | 6/20 | 0.54 |
| ▸ | PRKCE | Q02156 | 6/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 6/20 | 0.54 |
| ▸ | PRKCZ | Q05513 | 6/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.54 |
| ▸ | PRKD1 | Q15139 | 6/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319386 | 0.92 | FLT3 (0.56) | FLT3ROCK2ROCK1P2RX7PRKD3 | |
| SCHEMBL10496395 | 0.92 | FLT3 (0.55) | FLT3ROCK2ROCK1P2RX7PRKD3 | |
| SCHEMBL4729399 | 0.92 | PRKD3 (0.57) | FLT3ROCK2ROCK1P2RX7PRKD3 | |
| SCHEMBL4727549 | 0.90 | PRKD3 (0.64) | FLT3ROCK2ROCK1P2RX7PRKD3 | |
| SCHEMBL9542795 | 0.87 | PRKCG (0.68) | FLT3ROCK2ROCK1PRKD3PRKCG | |
| SCHEMBL30539980 | 0.86 | ROCK2 (0.62) | FLT3ROCK2ROCK1P2RX7PRKD3 | |
| SCHEMBL9016177 | 0.86 | ROCK2 (0.62) | FLT3ROCK2ROCK1P2RX7PRKD3 | |
| SCHEMBL9541277 | 0.84 | PRKCG (0.64) | FLT3ROCK2ROCK1P2RX7PRKD3 | |
| Hydrochloric Acid SCHEMBL9542896 | 0.83 | LMNA (0.65) | FLT3ROCK2ROCK1P2RX7PRKD3 | |
| SCHEMBL10979885 | 0.82 | ROCK2 (0.55) | FLT3ROCK2ROCK1P2RX7PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993013072-A1 | 5-ISOQUINOLINESULFONAMIDE DERIVATIVES AS PROTEIN KINASE INHIBITING AGENTS | ITALFARMACO S.P.A. (IT) | 1993-07-08 | — | — | WO | disclosed |