Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 2/20 | 0.55 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.55 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.55 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.55 |
| ▸ | PDE5A | O76074 | 2/20 | 0.52 |
| ▸ | PDE9A | O76083 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359701 | 0.85 | GRIA1 (0.58) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL8117343 | 0.84 | MEN1 (0.47) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL8345718 | 0.83 | MEN1 (0.51) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL7478166 | 0.83 | PDE5A (0.50) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL8345751 | 0.82 | PDE5A (0.46) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL7486477 | 0.81 | GRIA1 (0.58) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL24335140 | 0.81 | PDE5A (0.48) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL29580737 | 0.81 | PDE5A (0.48) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL7360391 | 0.81 | GRIA1 (0.59) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL9395706 | 0.81 | GRIA1 (0.51) | GRIA1GRIA2GRIA3GRIA4PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993008173-A1 | QUINOXALINE DERIVATES WITH AFFINITY FOR QUISQUALATE-RECEPTORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-04-29 | — | — | WO | disclosed |