Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 14/20 | 0.58 |
| ▸ | GRIA2 | P42262 | 14/20 | 0.58 |
| ▸ | GRIA3 | P42263 | 14/20 | 0.58 |
| ▸ | GRIA4 | P48058 | 14/20 | 0.58 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.58 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.58 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.58 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.58 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.58 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.58 |
| ▸ | GRIK1 | P39086 | 8/20 | 0.58 |
| ▸ | GRIK2 | Q13002 | 8/20 | 0.58 |
| ▸ | GRIK3 | Q13003 | 8/20 | 0.58 |
| ▸ | GRIK4 | Q16099 | 8/20 | 0.58 |
| ▸ | GRIK5 | Q16478 | 8/20 | 0.58 |
| ▸ | PDE5A | O76074 | 2/20 | 0.56 |
| ▸ | PDE9A | O76083 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9544064 | 0.85 | GRIA1 (0.55) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL7359093 | 0.83 | PDE5A (0.47) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7486477 | 0.83 | GRIA1 (0.58) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL7478166 | 0.83 | PDE5A (0.50) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8191230 | 0.82 | GRIA1 (0.62) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL24335140 | 0.81 | PDE5A (0.48) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL7360391 | 0.81 | GRIA1 (0.59) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL29580737 | 0.81 | PDE5A (0.48) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8345718 | 0.80 | MEN1 (0.51) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL9093930 | 0.80 | GRIA1 (0.62) | GRIA1GRIA2GRIA3GRIA4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |
| US-6057304-A | Quinoxaline-phosphonic acid derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |
| US-5955461-A | Quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-09-21 | — | — | US | disclosed |