Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.50 |
| ▸ | PDE9A | O76083 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24335140 | 0.92 | PDE5A (0.48) | PDE5APDE9AMEN1KMT2ACYP1A2 | |
| SCHEMBL29580737 | 0.92 | PDE5A (0.48) | PDE5APDE9AMEN1KMT2ACYP1A2 | |
| SCHEMBL8345718 | 0.86 | MEN1 (0.51) | PDE5APDE9AMEN1KMT2ACYP1A2 | |
| SCHEMBL8117343 | 0.84 | MEN1 (0.47) | PDE5APDE9AMEN1KMT2ACYP1A2 | |
| SCHEMBL9544064 | 0.83 | GRIA1 (0.55) | PDE5APDE9AMEN1KMT2ACYP1A2 | |
| SCHEMBL8346269 | 0.83 | MEN1 (0.46) | PDE5APDE9AMEN1KMT2ACYP1A2 | |
| SCHEMBL7359701 | 0.83 | GRIA1 (0.58) | PDE5APDE9AMEN1KMT2ACYP1A2 | |
| SCHEMBL29580281 | 0.82 | ALDH1A1 (0.48) | PDE5APDE9AMEN1KMT2ACYP1A2 | |
| SCHEMBL24335163 | 0.82 | ALDH1A1 (0.48) | PDE5APDE9AMEN1KMT2ACYP1A2 | |
| SCHEMBL7360391 | 0.82 | GRIA1 (0.59) | PDE5APDE9AMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799224-B1 | QUINOXALINES AND DRUGS PREPARED THEREFROM | BASF AG (DE) | 2002-04-17 | — | — | EP | disclosed |
| US-6277850-B1 | EFFICIENCY, BIOCOMPATIBILITY, TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ABBOTT LABORATORIES | 2001-08-21 | — | — | US | disclosed |
| EP-0696288-B1 | QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AG (DE) | 2000-09-20 | — | — | EP | disclosed |
| US-5955461-A | Quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-09-21 | — | — | US | disclosed |
| US-5849743-A | Quinoxalines and drugs prepared therefrom | BASF AKTIENGESELLSCHAFT (DE) | 1998-12-15 | — | — | US | disclosed |
| US-5750525-A | Quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-05-12 | — | — | US | disclosed |