Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432874 | 0.80 | TSHR (0.46) | ALDH1A1RAB9ACNR2SLC6A2SLC6A3 | |
| SCHEMBL16312132 | 0.75 | SLC6A2 (0.48) | HTTALDH1A1RAB9APYCR1CNR2 | |
| SCHEMBL9380682 | 0.73 | LMNA (0.46) | ALDH1A1RAB9ACNR2AOC3LMNA | |
| SCHEMBL8392172 | 0.71 | ALDH1A1 (0.49) | HTTALDH1A1RAB9APYCR1SLC6A2 | |
| SCHEMBL15178160 | 0.69 | SLC6A2 (0.52) | HTTSLC6A2SLC6A3HPGDSLC6A4 | |
| SCHEMBL10585879 | 0.69 | SLC6A2 (0.52) | HTTSLC6A2SLC6A3HPGDSLC6A4 | |
| SCHEMBL15701708 | 0.69 | KCNH2 (0.47) | CNR2SLC6A2SLC6A3SMN1; SMN2MAPT | |
| SCHEMBL128405 | 0.69 | — | — | |
| SCHEMBL11366830 | 0.69 | HRH3 (0.67) | HTTALDH1A1RAB9APYCR1KCNH2 | |
| SCHEMBL9681275 | 0.68 | ALDH1A1 (0.46) | HTTALDH1A1RAB9APYCR1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993011138-A1 | AMINE DERIVATIVES CONTAINING A PHOSPHONIC, PHOSPHONOUS OR PHOSPHINIC ACID MOIETY | JOHN WYETH & BROTHER LIMITED (GB) | 1993-06-10 | — | — | WO | disclosed |