SCHEMBL9544653

SCHEMBL9544653

CC1=C2CC[C@@H]3[C@H]([C@@H](F)C[C@@]4(C)[C@H]3CC[C@]4(C)O)[C@@]2(C)CC/C1=N\O

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SHBG P04278 2/20 0.35
ALDH1A1 P00352 1/20 0.35
NR3C1 P04150 1/20 0.35
PGR P06401 1/20 0.35
ADRA1A P35348 1/20 0.35
HTR2B P41595 1/20 0.35
CYP3A4 P08684 1/20 0.33
LMNA P02545 2/20 0.31
HIF1A Q16665 1/20 0.31
MAPT P10636 1/20 0.31
STS P08842 1/20 0.31
CYP19A1 P11511 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9542631 0.85 SHBG (0.34) SHBGALDH1A1NR3C1PGRADRA1A
SCHEMBL9541122 0.84 CYP3A4 (0.50) SHBGALDH1A1NR3C1PGRADRA1A
SCHEMBL9541134 0.84 CYP3A4 (0.50) SHBGALDH1A1NR3C1PGRADRA1A
SCHEMBL9541249 0.84 SHBG (0.33) SHBGALDH1A1NR3C1PGRADRA1A
SCHEMBL9541942 0.82 SHBG (0.50) SHBGALDH1A1NR3C1PGRADRA1A
SCHEMBL9543824 0.76 SHBG (0.35) SHBGALDH1A1NR3C1PGRADRA1A
SCHEMBL9126212 0.75 NR3C1 (0.47) SHBGALDH1A1NR3C1PGRADRA1A
SCHEMBL9126203 0.75 NR3C1 (0.47) SHBGALDH1A1NR3C1PGRADRA1A
SCHEMBL9126210 0.75 NR3C1 (0.47) SHBGALDH1A1NR3C1PGRADRA1A
SCHEMBL9542770 0.72 SHBG (0.50) SHBGALDH1A1NR3C1PGRADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993013122-A1 3-METHYLSULPHONYLHYDRAZONO AND 3-OXYIMINO STEROIDS, A METHOD OF PREPARING THEM, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE IN THE PREPARATION OF DRUGS SCHERING AKTIENGESELLSCHAFT (DE) 1993-07-08 WO disclosed